![]() ![]() All animals were raised in China Medical University Animal Center, 25 ☌ constant temperature (Humidity 50%), 12 h light:12 h dark cyclical alternates, with food and water available ad libitum. Sixty SPF grade female prepuberal C57BL/6 mice (21-day-old)were purchased from Beijing Vital River Laboratories animal co., LTD (license: SCXK(HU)2007–0003). ![]() In this experiment, we tried to gain a deeper understanding of the effect and mechanism of cinnamon on PCOS using a DHEA induced PCOS like mice model. Previous studies proved dehydroepiandrosterone (DHEA) induced PCOS model represents similar characteristic seen in human patients, such as hyperandrogenism, abnormal maturation of ovarian follicles and anovulation. Based on these findings, we put forward our hypothesis that cinnamon has an overall impact on PCOS treatment. Oral cinnamon extract reduced fasting glucose, triglycerides, low-density lipoprotein (LDL), and total cholesterol in patients with type 2 diabetes mellitus, as well as improved insulin sensitivity in women with PCOS. Through these two mechanisms cinnamon extract make adipocytes to increase the glucose uptake and glycogen synthesis. The extracts from cinnamon stimulate autophosphorylation of the insulin receptor and inhibit protein tyrosine phosphatase I. Several in vitro and in vivo studies have shown cinnamon can reduce insulin resistance by increasing activation of the IRS/PI-3 kinase insulin signalling pathway. In a high-fructose diet induce insulin resistance rat model, cinnamon extract not only improves systemic insulin sensitivity and dyslipidemia by enhancing insulin signaling, but also effectively ameliorates circulating levels of adipokines partially mediated via regulation of the expression of multiple genes involved in insulin sensitivity and lipogenesis. Cinnamon, which is a spice used to flavor foods, has been shown to possess anti-PCOS and anti-diabetic properties. Under such circumstances, Nutraceuticals may represent a valuable alternative or adjunct to lifestyle interventions and conventional prescription drugs. Īlthough the etiology of PCOS is still unclear, what we know is that genetic and environmental factors contribute to the origin and development of this disorder. Hyperinsulinemia may promote abnormal androgen secretion and disrupt folliculogenesis and menstrual cyclicity which are the main characteristics of PCOS. The prevalence of insulin resistance and the compensatory hyperinsulinemia among women with PCOS is 50–70% and may be as high as 95% in overweight women. Women with PCOS are at increased risk of reproductive abnormalities, and two-thirds of them also have metabolic dysfunction and, thereby, have an increased risk of developing type 2 diabetes mellitus and cardiovascular disease. Most of the patients also have metabolic abnormalities, such as obesity, dyslipidemia, and insulin resistance. The manifestation of this syndrome includes oligomenhorrhea, amenorrhea, anovulation, numerous antral follicles, hypersecretion of circulating LH but with lower or equivalent FSH levels, hyperandrogenemia and hirsutism. Polycystic ovary syndrome (PCOS) is one of the most common, complex and heterogeneous endocrine disorders affecting 5–10% of women of fertile age. Cinnamon also attenuates DHEA induced a higher IGF-1 and lower IGFBP-1 expression in ovary by immunohistochemistry. There are significant differences of serum level of total testosterone (0.033 ± 0.009 ng/ml), among control group, DHEA and cinnamon group (0.052 ± 0.011 ng/ml), and DHEA group (0.079 ± 0.015 ng/ml) There was an increasing tendency of serum FSH level from DHEA group (5.02 ± 0.31 ng/ml), DHEA and cinnamon group (5.81 ± 0.51 ng/ml), to control group (7.13 ± 0.74 ng/ml) and there was a decreasing trend of serum LH level from DHEA group (3.75 ± 0.57 ng/ml), DHEA and cinnamon group (1.35 ± 0.61 ng/ml), or control group (0.69 ± 0.34 ng/ml) serum insulin level is significantly higher in DHEA treated mice (1.61 ± 0.31 ng/ml) than control group (0.93 ± 0.19 ng/ml), or DHEA and cinnamon effect (1.27 ± 0.23 ng/ml) ( p < 0.05). Cinnamon restores the cyclicity and ovary morphology in PCOS mice model induced by DHEA. ![]()
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